The Complete Kratom Guide

Kratom Active Alkaloids

There are 40 compounds found in Kratom leaves ncluding many alkaloids such as mitragynine (once thought to be the primary active constituent), mitraphylline, and 7-hydroxymitragynine. Other active chemicals include raubasine and some yohimbe alkaloids such as corynantheidine. Kratom (Mitragyna speciosa) also contains at least one alkaloid called rhynchophylline (NMDA antagonist) that is a calcium channel blocker.

One analysis of kratom, using liquid chromatography-electrospray ionization mass spectrometry found mitragynine at levels of 1-6% and 7-hydroxymirtrogynine at levels of 0.01-0.04%. The chemical structure of mitragynines incorporate the nucleus of the tryptamine, and these may be responsible for the molecules which are observed in the serotonin and adrnergic systems. In mitragynine, the phenolic methyl ether is considered to be stronger in analgesic paradigms according to some studies.

Important Disclaimer

These statements have not been evaluated by the Food & Drug Administration. Kratom is not intended to diagnose, treat, cure or prevent any disease. Consult your healthcare professional prior to use if you have or suspect a medical condition. If you are under medical supervision, are using anti-depressants, anti-anxiety medications, diabetes medications, narcotics, blood pressure medication, sedatives, tranquilizers or asthma medication, seek the advice of your healthcare professional prior to use. Do not use if you are pregnant, lactating or under the age of 18 years. Do not take when operating machinery or driving. Keep out of reach of children.

The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. Please, consult your physician.

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